Detalhe da pesquisa
1.
Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents.
Biochemistry
; 58(6): 833-847, 2019 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30582694
2.
Mycobacteria Encode Active and Inactive Classes of TesB Fatty-Acyl CoA Thioesterases Revealed through Structural and Functional Analysis.
Biochemistry
; 56(10): 1460-1472, 2017 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28156101
3.
Biosynthesis of mycobacterial lipids by polyketide synthases and beyond.
Crit Rev Biochem Mol Biol
; 49(3): 179-211, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24625105
4.
Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.
Bioorg Med Chem Lett
; 26(21): 5340-5345, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27692545
5.
Biosynthesis of cell envelope-associated phenolic glycolipids in Mycobacterium marinum.
J Bacteriol
; 197(6): 1040-50, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25561717
6.
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.
Bioorg Med Chem Lett
; 24(16): 4035-8, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25011911
7.
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
Antimicrob Agents Chemother
; 57(10): 5138-40, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856770
8.
Comprehensive essentiality analysis of the Mycobacterium kansasii genome by saturation transposon mutagenesis and deep sequencing.
mBio
; 14(4): e0057323, 2023 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37350613
9.
Genetic Underpinnings of Carotenogenesis and Light-Induced Transcriptome Remodeling in the Opportunistic Pathogen Mycobacterium kansasii.
Pathogens
; 12(1)2023 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36678434
10.
Inactivation of tesA reduces cell wall lipid production and increases drug susceptibility in mycobacteria.
J Biol Chem
; 286(28): 24616-25, 2011 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21592957
11.
The mycobacterial acyltransferase PapA5 is required for biosynthesis of cell wall-associated phenolic glycolipids.
Microbiology (Reading)
; 158(Pt 5): 1379-1387, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22361940
12.
Production of mycobacterial cell wall glycopeptidolipids requires a member of the MbtH-like protein family.
BMC Microbiol
; 12: 118, 2012 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22726990
13.
Mycobacterium abscessus Mutants with a Compromised Functional Link between the Type VII ESX-3 System and an Iron Uptake Mechanism Reliant on an Unusual Mycobactin Siderophore.
Pathogens
; 11(9)2022 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36145386
14.
Mutational and phylogenetic analyses of the mycobacterial mbt gene cluster.
J Bacteriol
; 193(21): 5905-13, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21873494
15.
Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.
Bioorg Med Chem Lett
; 21(21): 6533-7, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21940166
16.
Transposon mutagenesis in Mycobacterium kansasii links a small RNA gene to colony morphology and biofilm formation and identifies 9,885 intragenic insertions that do not compromise colony outgrowth.
Microbiologyopen
; 9(4): e988, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32083796
17.
Cooperation between a coenzyme A-independent stand-alone initiation module and an iterative type I polyketide synthase during synthesis of mycobacterial phenolic glycolipids.
J Am Chem Soc
; 131(46): 16744-50, 2009 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19799378
18.
Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells.
Respir Res
; 10: 26, 2009 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19344509
19.
Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation.
Chem Biol
; 15(1): 51-61, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18158259
20.
Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.
Bioorg Med Chem Lett
; 18(8): 2662-8, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18394884